Pub. Date : 2009 Apr 30
PMID : 19390822
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Intradermally injected carrageenan caused elevated number of cells exhibiting Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn, and decreased the thermal and mechanical threshold in Hargreaves and von Frey tests. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Intradermally injected carrageenan caused elevated number of cells exhibiting Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn, and decreased the thermal and mechanical threshold in Hargreaves and von Frey tests. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Pretreatment with an inhibitor of phospholipase A2, that generates the LO substrate, prior to the carrageenan injection significantly reduced the number of Fos-(+) cells. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Moreover, the LO inhibitors suppressed carrageenan-induced thermal and mechanical hyperalgesic behaviors, which inidcates that the changes in Fos expression correlates with those in the nociceptive behaviors in the inflamed rats. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | Overall, our results from the Fos-LI and behavior tests suggest that LO products released from inflamed tissues contribute to nociception during carrageenan-induced inflammation, indicating that the LO pathway is a possible target for modulating inflammatory pain. | Carrageenan | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |