Pub. Date : 2009 Jul
PMID : 19389858
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |
| 2 | The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |
| 3 | The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |
| 4 | The concentrations of trospium chloride in the brain were up to 7 times higher in the mdr1a,b(-/-) knockout mice compared with wild-type mice (p < 0.05), making P-gp a limiting factor for the blood-brain barrier penetration of this drug. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |
| 5 | Apart from the blood-brain barrier, P-gp also had significant effects on the overall pharmacokinetics of trospium chloride. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |
| 6 | Our study indicates that the multidrug resistance transporter P-gp is a major determinant for the distribution of trospium chloride in the body and highly restricts its entry into the brain. | trospium chloride | phosphoglycolate phosphatase | Mus musculus |