PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19389858-0	2009	The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride.	trospium chloride	124-141	phosphoglycolate phosphatase	Mus musculus	12-26	
19389858-1	2009	The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder.	trospium chloride	134-151	phosphoglycolate phosphatase	Mus musculus	89-103	
19389858-1	2009	The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder.	trospium chloride	134-151	phosphoglycolate phosphatase	Mus musculus	105-109	
19389858-3	2009	The concentrations of trospium chloride in the brain were up to 7 times higher in the mdr1a,b(-/-) knockout mice compared with wild-type mice (p < 0.05), making P-gp a limiting factor for the blood-brain barrier penetration of this drug.	trospium chloride	22-39	phosphoglycolate phosphatase	Mus musculus	164-168	
19389858-5	2009	Apart from the blood-brain barrier, P-gp also had significant effects on the overall pharmacokinetics of trospium chloride.	trospium chloride	105-122	phosphoglycolate phosphatase	Mus musculus	36-40	
19389858-7	2009	Our study indicates that the multidrug resistance transporter P-gp is a major determinant for the distribution of trospium chloride in the body and highly restricts its entry into the brain.	trospium chloride	114-131	phosphoglycolate phosphatase	Mus musculus	62-66