Pub. Date : 2009 May 1
PMID : 19383815
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. | 7-hydroxymethotrexate | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus | ||
| 2 | Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. | 7-hydroxymethotrexate | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus | ||
| 3 | We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX). | 7-hydroxymethotrexate | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus | ||
| 4 | We additionally found that in the absence of Abcc2, Abcg2 mediated substantial urinary excretion of MTX and 7OH-MTX. | 7-hydroxymethotrexate | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus | ||
| 5 | CONCLUSIONS: Abcc2 and Abcg2 together are major determinants of MTX and 7OH-MTX pharmacokinetics. | 7-hydroxymethotrexate | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus | ||