Pub. Date : 2009 Jun 12
PMID : 19379130
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides. | Hydroxylamine | myeloperoxidase | Homo sapiens |
| 2 | However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl production by MPO and by neutrophils with IC50 values of approx. | Hydroxylamine | myeloperoxidase | Homo sapiens |
| 3 | However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl production by MPO and by neutrophils with IC50 values of approx. | Hydroxylamine | myeloperoxidase | Homo sapiens |
| 4 | Inhibition was shown to involve one-electron oxidation of the nitroxides by the compound I form of MPO and accumulation of compound II. | Hydroxylamine | myeloperoxidase | Homo sapiens |
| 5 | Overall, these data indicate that nitroxides have considerable promise as therapeutic agents for the inhibition of MPO-mediated damage in inflammatory diseases. | Hydroxylamine | myeloperoxidase | Homo sapiens |