Title : Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages.

Pub. Date : 2009 Apr 15

PMID : 19371603






2 Functional Relationships(s)
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1 Our studies show that exposure to acrolein resulted in the secretion of MMP-9 from differentiated THP-1 macrophages. Acrolein matrix metallopeptidase 9 Mus musculus
2 These observations suggest that acrolein exposure results in MMP secretion from macrophages via a mechanism that involves an increase in [Ca2+](I), leading to xanthine oxidase activation and an increase in ROS production. Acrolein matrix metallopeptidase 9 Mus musculus