Title : Correlation of therapeutic effect of obidoxime and dosing time in the acute intoxication by chlorfenvinphos in rats.

Pub. Date : 2009 Jul

PMID : 19371264






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1 The ability of obidoxime with atropine and diazepam mixture to reactivate acetylcholinesterase inhibited by the organophosphorus compound chlorfenvinphos was compared in the central nervous system and peripheral tissues of rats. Diazepam acetylcholinesterase Rattus norvegicus
2 The results of the present study show that obidoxime administered separately and jointly with atropine and diazepam 24 hrs after intoxication was effective on reactivation of chlorfenvinphos-inhibited acetylcholinesterase in the central nervous system and in the peripheral tissues. Diazepam acetylcholinesterase Rattus norvegicus