Title : Effects of 1,25-dihydroxycholecalciferol and calcium on calcitonin mRNA levels in suckling rats.

Pub. Date : 1991 Aug

PMID : 1936545






7 Functional Relationships(s)
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1 Effects of 1,25-dihydroxycholecalciferol and calcium on calcitonin mRNA levels in suckling rats. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
2 Thyroidal CT contents were decreased in relation to increased plasma calcium levels in animals treated with 0.1 or 1 microgram 1,25-(OH)2D3/kg. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
3 Intraperitoneal calcium administration in fasted 13-day-old rats was associated with a 5-fold increase in plasma CT 30 min after injection, but CT mRNA levels were unchanged within 240 min. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
4 By contrast, stomach gavage with calcium in fasted 13-day-old rats induced a sustained increase in plasma CT (X2), and a 4-fold increase in the steady-state level of CT mRNA. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
5 By contrast, stomach gavage with calcium in fasted 13-day-old rats induced a sustained increase in plasma CT (X2), and a 4-fold increase in the steady-state level of CT mRNA. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
6 Calcium per se is a potent stimulator of CT release in suckling rats, but did not change the amount of CT mRNA. Calcium calcitonin-related polypeptide alpha Rattus norvegicus
7 However, gastrointestinal factors may be implied directly or indirectly in the increased CT mRNA level after calcium gavage. Calcium calcitonin-related polypeptide alpha Rattus norvegicus