Pub. Date : 2009 Jul 7
PMID : 19362120
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 2 | Ghrelin induces orexigenic behavior by activation of growth hormone secretagogue 1 receptors (GHSRs) in the ventral tegmental area (VTA) as well as hypothalamus, suggesting the involvement of mesolimbic dopamine system in the action of ghrelin. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 3 | Ghrelin induces orexigenic behavior by activation of growth hormone secretagogue 1 receptors (GHSRs) in the ventral tegmental area (VTA) as well as hypothalamus, suggesting the involvement of mesolimbic dopamine system in the action of ghrelin. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 4 | The present study aimed to identify neuronal mechanisms by which peripherally administered ghrelin regulates the mesolimbic dopamine system under different food-consumptive states. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 5 | Peripheral administration of ghrelin decreased dopamine levels in the NAc when food was removed following ghrelin administration. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 6 | Peripheral administration of ghrelin decreased dopamine levels in the NAc when food was removed following ghrelin administration. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 7 | In contrast, when animals consumed food following ghrelin administration, dopamine levels increased robustly. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 8 | Furthermore, local injection of ghrelin into the VTA induced dopamine release in the NAc and food consumption, supporting the local action of ghrelin in the VTA. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 9 | Furthermore, local injection of ghrelin into the VTA induced dopamine release in the NAc and food consumption, supporting the local action of ghrelin in the VTA. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 10 | In conclusion, peripherally administered ghrelin activates GHSRs in the VTA, and induces bimodal effects on mesolimbic dopamine neurotransmission depending on food-consumptive states. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |