Title : Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins.

Pub. Date : 2009 Jun

PMID : 19359419






10 Functional Relationships(s)
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1 Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins. Heparin stabilin 2 Homo sapiens
2 Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins. Heparin stabilin 2 Homo sapiens
3 The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH. Heparin stabilin 2 Homo sapiens
4 The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH. Heparin stabilin 2 Homo sapiens
5 In this study, we demonstrate that anti-HARE antibodies specifically block the uptake of LMWH and UFH by isolated rat liver SECs and by human 293 cells expressing recombinant human HARE (hHARE). Heparin stabilin 2 Homo sapiens
6 We conclude that both UFH and LMWH are cleared by HARE/Stab2 and that the differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. Heparin stabilin 2 Homo sapiens
7 We conclude that both UFH and LMWH are cleared by HARE/Stab2 and that the differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. Heparin stabilin 2 Homo sapiens
8 We conclude that both UFH and LMWH are cleared by HARE/Stab2 and that the differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. Heparin stabilin 2 Homo sapiens
9 We conclude that both UFH and LMWH are cleared by HARE/Stab2 and that the differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. Heparin stabilin 2 Homo sapiens
10 We conclude that both UFH and LMWH are cleared by HARE/Stab2 and that the differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. Heparin stabilin 2 Homo sapiens