Title : Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats.

Pub. Date : 2009 Jun

PMID : 19357830






3 Functional Relationships(s)
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1 Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats. Serine potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus
2 The serine residue at amino acid position 385 of Kir6.2 was found to be the substrate phosphorylation site of AMPK when activated by rosiglitazone or AICAR. Serine potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus
3 Phosphorylation of the Ser(385) residue of the Kir6.2 subunit of the K(ATP) channel by AMPK may play a role in insulin secretion. Serine potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus