Title : Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42.

Pub. Date : 2009 Mar 27

PMID : 19356586






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The selectivity in nucleotide exchange kinetics for GDP over GTP is even more pronounced when a Cdc42 mutant, F28L, is used, which is characterised by fast intrinsic dissociation of nucleotides. Guanosine Diphosphate cell division cycle 42 Homo sapiens
2 The higher exchange activity of ITSN1L towards the GDP-bound conformation of Cdc42 could represent an evolutionary adaptation of this GEF that ensures nucleotide exchange towards the formation of the signalling-active GTP-bound form of Cdc42 and avoids dissociation of the active complex. Guanosine Diphosphate cell division cycle 42 Homo sapiens
3 The higher exchange activity of ITSN1L towards the GDP-bound conformation of Cdc42 could represent an evolutionary adaptation of this GEF that ensures nucleotide exchange towards the formation of the signalling-active GTP-bound form of Cdc42 and avoids dissociation of the active complex. Guanosine Diphosphate cell division cycle 42 Homo sapiens