Title : Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase.

Pub. Date : 2008 Aug

PMID : 19356092






1 Functional Relationships(s)
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1 The influence of the enzyme source such as phospholipid and expression ratio of NADPH-cytochrome P450 reductase on midazolam 1"-hydroxylation activity of cytochrome P450 3A4 was investigated in reconstituted systems and in membranes using bicistronic expressions. Phospholipids cytochrome P450 family 3 subfamily A member 4 Homo sapiens