Title : A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia.

Pub. Date : 2009 May

PMID : 19339913






2 Functional Relationships(s)
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1 OBJECTIVES: Oxidation of vitamin B12 by nitrous oxide leads to the inactivation of methionine synthase resulting in elevated plasma total homocysteine concentrations. Nitrous Oxide 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
2 The average increase in plasma homocysteine was 2.4 mumol/l (+28%) in all three groups indicating the expected inactivation of methionine synthase by nitrous oxide through oxidation of vitamin B12, but no genetic effect. Nitrous Oxide 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens