Pub. Date : 2009 Jul
PMID : 19308943
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We hypothesized that Hcy causes cerebrovascular remodeling by increasing redox stress and MMP-9 activity via the extracellular signal-regulated kinase (ERK) signaling pathway and by inhibition of GABA-A receptors, thus behaving as an inhibitory neurotransmitter. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | We hypothesized that Hcy causes cerebrovascular remodeling by increasing redox stress and MMP-9 activity via the extracellular signal-regulated kinase (ERK) signaling pathway and by inhibition of GABA-A receptors, thus behaving as an inhibitory neurotransmitter. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In parallel, Hcy caused phosphorylation of ERK and selectively decreased levels of tissue inhibitors of metalloproteinase-4 (TIMP-4). | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Furthermore muscimol attenuated Hcy-induced MMP-9 via ERK signaling pathway. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | These results suggest that Hcy competes with GABA-A receptors, inducing the oxidative stress transduction pathway and leading to ERK activation. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |