Title : Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesia.

Pub. Date : 2009 Aug

PMID : 19299480






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK-dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 (mPGES-1) in astrocytes and p38-dependent up-regulation of IL-6 in microglia in the rat spinal cord. Morphine tumor necrosis factor Rattus norvegicus
2 Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1. Morphine tumor necrosis factor Rattus norvegicus