Pub. Date : 2009 Aug
PMID : 19299480
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK-dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 (mPGES-1) in astrocytes and p38-dependent up-regulation of IL-6 in microglia in the rat spinal cord. | Morphine | tumor necrosis factor | Rattus norvegicus |
2 | Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1. | Morphine | tumor necrosis factor | Rattus norvegicus |