Pub. Date : 2009 Mar 13
PMID : 19285025
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased expression levels of HER1, HER2 and the estrogen receptor (ER)-AIB1 complex were found in tamoxifen-resistant cells. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 2 | EGF stimulation and gefitinib inhibition experiments further demonstrated that HER1/HER2 signaling and AIB1 were involved in the proliferation of cells that had acquired Tam resistance. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 3 | Thus, AIB1 may be a new therapeutic target, and the removal of AIB1 may decrease the crosstalk between ER and the HER1/HER2 pathway, resulting in the restoration of tamoxifen sensitivity in tamoxifen-resistant cells. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 4 | Thus, AIB1 may be a new therapeutic target, and the removal of AIB1 may decrease the crosstalk between ER and the HER1/HER2 pathway, resulting in the restoration of tamoxifen sensitivity in tamoxifen-resistant cells. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |