Pub. Date : 2009 Mar
PMID : 19277407
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Experimental studies have shown increased synthesis and release of tissue factor pathway inhibitor (TFPI) by physiological levels of testosterone in endothelial cells. | Testosterone | tissue factor pathway inhibitor | Homo sapiens |
| 2 | Experimental studies have shown increased synthesis and release of tissue factor pathway inhibitor (TFPI) by physiological levels of testosterone in endothelial cells. | Testosterone | tissue factor pathway inhibitor | Homo sapiens |
| 3 | Our hypothesis was that elderly men with low testosterone levels would have lower plasma levels of plasma free TFPI with subsequent increased thrombin generation. | Testosterone | tissue factor pathway inhibitor | Homo sapiens |
| 4 | Elderly men with low testosterone levels had lower plasma free TFPI Ag (10.9 +/- 2.3 ng/ml vs. 12.3 +/- 3.0 ng/ml, p = 0.027) and shorter initiation phase of TF-induced coagulation assessed by lag-time (5.1 +/- 1.0 min vs. 5.7 +/- 1.3, p = 0.039). | Testosterone | tissue factor pathway inhibitor | Homo sapiens |
| 5 | Multiple regression analysis revealed that total and free testosterone were independent predictors of plasma free TFPI Ag. | Testosterone | tissue factor pathway inhibitor | Homo sapiens |
| 6 | Our findings suggest that low testosterone levels in elderly men is associated with low plasma free TFPI Ag and subsequent shortened initiation phase of TF-induced coagulation. | Testosterone | tissue factor pathway inhibitor | Homo sapiens |