Pub. Date : 2009 May
PMID : 19273609
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 2 | We identify tyrosine phosphorylation of the growth factor receptor-bound protein 2 (Grb2) as a critical mechanism by which PRL antagonizes EGF-induced cell proliferation by attenuating the activation of the Ras/mitogen-activated protein kinase (MAPK) pathway. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 3 | We identify tyrosine phosphorylation of the growth factor receptor-bound protein 2 (Grb2) as a critical mechanism by which PRL antagonizes EGF-induced cell proliferation by attenuating the activation of the Ras/mitogen-activated protein kinase (MAPK) pathway. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 4 | Together, our results define a novel negative cross-regulation between PRL and EGF involving the Jak2/Stat5a and Ras/MAPK pathways through tyrosine phosphorylation of Grb2. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |