Title : Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.

Pub. Date : 2009

PMID : 19262751






1 Functional Relationships(s)
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1 The finding that in normal cells Parp1 and ADP-ribose polymers localize on the Dnmt1 promoter raises the possibility that PARylated Parp1 marks those sequences in the genome that must remain unmethylated and protects them from methylation, thus playing a role in the epigenetic regulation of gene expression. Ribose poly (ADP-ribose) polymerase family, member 1 Mus musculus