Title : Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.

Pub. Date : 2009 Aug 14

PMID : 19261608






2 Functional Relationships(s)
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1 The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens