Title : ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway.

Pub. Date : 2009 May

PMID : 19246337






1 Functional Relationships(s)
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1 Treatment with ABT-737 plus chemotherapy resulted in dramatic up-regulation of proapoptotic Noxa protein, and small interfering RNA (siRNA)-mediated inhibition of Noxa up-regulation partially attenuated cell death by the synergistic combination. ABT-737 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens