Pub. Date : 2009
PMID : 19239702
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | We hypothesized that cyclin-dependent kinase (CDK) 1 activity and CDK2 activity in cancer cells, which reflect the activation state of the spindle assembly checkpoint and the growth state, respectively, predict sensitivity to paclitaxel. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 6 | CONCLUSIONS: The change in CDK1 specific activity of xenograft tumors after paclitaxel treatment and the CDK2 specific activity before paclitaxel treatment are both associated with the drug sensitivity in vivo. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 7 | CONCLUSIONS: The change in CDK1 specific activity of xenograft tumors after paclitaxel treatment and the CDK2 specific activity before paclitaxel treatment are both associated with the drug sensitivity in vivo. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |