Pub. Date : 2008 Oct
PMID : 19238654
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The mean increase in the repaglinide area under the plasma concentration-time curve from 0 h to infinity (AUC(0-infinity)) produced by gemfibrozil was larger in individuals with the SLCO1B1 c.521CC genotype (n = 6) than in those with the c.521TC (n = 6) and c.521TT (n = 12) genotypes, by factors of 1.56 (P = 0.004) and 1.54 (P = 0.002), respectively. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | In conclusion, the extent of gemfibrozil-repaglinide interaction depends on SLCO1B1 genotype. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | Atorvastatin raises plasma repaglinide concentrations, probably by inhibiting organic anion transporting polypeptide 1B1 (OATP1B1). | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | Atorvastatin raises plasma repaglinide concentrations, probably by inhibiting organic anion transporting polypeptide 1B1 (OATP1B1). | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |