Pub. Date : 2009
PMID : 19238206
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 2 | Here we report for the first time that PHB interacts with O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) and is O-GlcNAc modified; and also undergoes tyrosine phosphorylation in response to insulin. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 3 | Tyrosine 114 (Tyr114) and tyrosine 259 (Tyr259) in PHB are in the close proximity of potential O-GlcNAc sites serine 121 (Ser121) and threonine 258 (Thr258) respectively. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 4 | Tyrosine 114 (Tyr114) and tyrosine 259 (Tyr259) in PHB are in the close proximity of potential O-GlcNAc sites serine 121 (Ser121) and threonine 258 (Thr258) respectively. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 5 | This is attributed to the presence of similar tyrosine motifs in PHB and OGT. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 6 | Sequence analysis of O-GlcNAc modified proteins having known O-GlcNAc modification site(s) or known tyrosine phosphorylation site(s) revealed a strong potential association between these two posttranslational modifications in various proteins. | Tyrosine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |