Pub. Date : 2009 Mar 1
PMID : 19234185
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 2 | Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 3 | Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 4 | Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 5 | Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 6 | Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 7 | Steady-state concentrations of NAD(+) and ATP in extracellular compartments are highly regulated and usually are well below the threshold required for activating P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 8 | We show that lysis of erythrocytes releases sufficient levels of NAD(+) and ATP to induce activation of P2X(7). | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 9 | We further show that the routine preparation of primary lymph node and spleen cells induces the release of NAD(+) in sufficient concentrations for ART2.2 to ADP-ribosylate P2X(7), even at 4 degrees C. Gating of P2X(7) occurs when T cells are returned to 37 degrees C, rapidly inducing CD62L-shedding and PS-externalization by a substantial fraction of the cells. | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 10 | We further show that the routine preparation of primary lymph node and spleen cells induces the release of NAD(+) in sufficient concentrations for ART2.2 to ADP-ribosylate P2X(7), even at 4 degrees C. Gating of P2X(7) occurs when T cells are returned to 37 degrees C, rapidly inducing CD62L-shedding and PS-externalization by a substantial fraction of the cells. | NAD | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |