Protein Name purinergic receptor P2X, ligand-gated ion channel, 7
Organism Mus musculus
Gene ID 18439
Gene Symbol

P2rx7

UniProt Q9Z1M0 (P2RX7_MOUSE), Q6P5P0 (Q6P5P0_MOUSE), Q3UN00 (Q3UN00_MOUSE), C8YIX4 (C8YIX4_MOUSE), Q8CHP4 (Q8CHP4_MOUSE), F8WI93 (F8WI93_MOUSE)
Relationships Total Number of functionally related compound(s) : 381
Total Number of Articles : 596
Description

purinergic receptor P2X, ligand-gated ion channel, 7

Gene Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • P2X purinoceptor 7
  • ATP receptor
  • P2X7 purinoceptor
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Properties