Pub. Date : 2009 Feb 15
PMID : 19228734
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Here, we studied whether overexpression of ErbB2 may lead to mitotic deregulation in breast cancer cells via up-regulation of survivin that confers Taxol resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | EXPERIMENTAL DESIGN: ErbB2-overexpressing and ErbB2-low-expressing breast cancer cell lines were used to compare their mitotic exit rate, survivin expression level, and apoptosis level in response to Taxol. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | ErbB2-overexpressing cells exited M phase faster than ErbB2-low-expressing cells, which correlated with the increased resistance to Taxol-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | In addition, combination treatment of Taxol with PI3K/Akt and Src inhibitor led to increased apoptosis in ErbB2-overexpressing breast cancer cells than single treatment. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | CONCLUSIONS: Survivin up-regulation by ErbB2 is a critical event in ErbB2-mediated faster mitotic exit and contributes to Taxol resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | CONCLUSIONS: Survivin up-regulation by ErbB2 is a critical event in ErbB2-mediated faster mitotic exit and contributes to Taxol resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |