Title : The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.

Pub. Date : 2009 May

PMID : 19225039






4 Functional Relationships(s)
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1 Four drugs, flavopiridol, imatinib mesylate (Gleevec), PF-407288, and prazosin, with different transport specificity for BCRP/Bcrp and MDR1/Mdr1a were selected, and the drug levels in plasma, cerebrospinal fluid, and brain of mice were determined. Prazosin ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus
2 Four drugs, flavopiridol, imatinib mesylate (Gleevec), PF-407288, and prazosin, with different transport specificity for BCRP/Bcrp and MDR1/Mdr1a were selected, and the drug levels in plasma, cerebrospinal fluid, and brain of mice were determined. Prazosin ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus
3 Flavopiridol and prazosin were identified as substrates for both mouse Bcrp and Mdr1a with greater transport associated with Bcrp. Prazosin ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus
4 Flavopiridol and prazosin were identified as substrates for both mouse Bcrp and Mdr1a with greater transport associated with Bcrp. Prazosin ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus