Title : Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change.

Pub. Date : 2009 Aug

PMID : 19224363






2 Functional Relationships(s)
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1 7-Ketocholesterol induced the nuclear damage, loss of the mitochondrial transmembrane potential, increase in the cytosolic Bax and cytochrome c levels, caspase-3 activation and cell death in differentiated PC12 cells. 7-ketocholesterol caspase 3 Rattus norvegicus
2 Glycyrrhizin and 18beta-glycyrrhetinic acid prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death. 7-ketocholesterol caspase 3 Rattus norvegicus