Pub. Date : 2009
PMID : 19221419
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling. | Tyrosine | amyloid beta precursor protein binding family B member 1 | Homo sapiens |
| 2 | Here we report that phosphorylation of Tyr-682 inhibits the interactions between AbetaPP and Fe65, which is the main regulatory mechanism controlling Fe65 nuclear signaling. | Tyrosine | amyloid beta precursor protein binding family B member 1 | Homo sapiens |
| 3 | Here we report that phosphorylation of Tyr-682 inhibits the interactions between AbetaPP and Fe65, which is the main regulatory mechanism controlling Fe65 nuclear signaling. | Tyrosine | amyloid beta precursor protein binding family B member 1 | Homo sapiens |
| 4 | Furthermore, we show that tyrosine phosphorylation of AbetaPP also inhibits interaction of the two other Fe65 family members, Fe65L1 and Fe65L2. | Tyrosine | amyloid beta precursor protein binding family B member 1 | Homo sapiens |
| 5 | Our results indicate that phosphorylation of the cytoplasmic tail of AbetaPP on Tyr-682 represents a second mechanism, alternative to AbetaPP processing by secretases, that regulates AbetaPP/Fe65 downstream signaling pathways. | Tyrosine | amyloid beta precursor protein binding family B member 1 | Homo sapiens |