Title : 14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia.

Pub. Date : 2009 Jun

PMID : 19220809






1 Functional Relationships(s)
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1 In particular, constitutive tyrosine kinase (TK) activity of p210 BCR-ABL blocks c-Jun N-terminal kinase (JNK) phosphorylation leading to 14-3-3 sigma phosphorylation at a critical residue (Ser(186)) for c-ABL binding in response to DNA damage. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens