Title : A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice.

Pub. Date : 2009 Nov

PMID : 19202006






1 Functional Relationships(s)
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1 In cultured human BSM cells, IL-13 (100 ng/ml) caused a phosphorylation of STAT6 and an up-regulation of RhoA, a monomeric GTPase responsible for Ca2+ sensitization of smooth muscle contraction: both events were inhibited by co-incubation with AS1517499 (100 nM). 4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide interleukin 13 Homo sapiens