Title : In vitro replication and repair studies of tandem lesions containing neighboring thymidine glycol and 8-oxo-7,8-dihydro-2'-deoxyguanosine.

Pub. Date : 2009 Mar 16

PMID : 19193190






3 Functional Relationships(s)
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1 Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1. Thioguanine 8-oxoguanine DNA glycosylase Homo sapiens
2 Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1. Thioguanine 8-oxoguanine DNA glycosylase Homo sapiens
3 Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1. Thioguanine 8-oxoguanine DNA glycosylase Homo sapiens