Title : Tissue plasminogen activator modulates the cellular and behavioral response to cocaine.

Pub. Date : 2009 Feb 10

PMID : 19181855






2 Functional Relationships(s)
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1 Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc). Cocaine protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus
2 Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc). Cocaine protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus