Pub. Date : 2009 Feb 4
PMID : 19176463
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. | benzyl isothiocyanate | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | The effects of BITC treatment on tumor growth, apoptosis, and STAT-3 protein expression in vivo were studied in xenografts of BxPC-3 pancreatic tumor cells in athymic nude mice. | benzyl isothiocyanate | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Overexpression of STAT-3 in BxPC-3 cells inhibited BITC-induced apoptosis and restored STAT-3 activity. | benzyl isothiocyanate | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | CONCLUSION: BITC induces apoptosis in some types of pancreatic cancer cells by inhibiting the STAT-3 signaling pathway. | benzyl isothiocyanate | signal transducer and activator of transcription 3 | Homo sapiens |