Pub. Date : 2009 Feb 1
PMID : 19176374
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | In tumor xenograft studies, IP6 (2% w/v, in drinking water) caused a comparable reduction in tumor volume (40-46%) and tumor cell proliferation (26-28%) in DU-EV (control), DU-p21, and DU-p27 tumors but lost most of its effect in DU-p21+p27 tumors. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | In tumor xenograft studies, IP6 (2% w/v, in drinking water) caused a comparable reduction in tumor volume (40-46%) and tumor cell proliferation (26-28%) in DU-EV (control), DU-p21, and DU-p27 tumors but lost most of its effect in DU-p21+p27 tumors. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 9 | IP6-caused apoptosis also occurred in a Cip/Kip-dependent manner because DU-p21+p27 cells were completely resistant to IP6-induced apoptosis both in cell culture and xenograft. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 10 | IP6-caused apoptosis also occurred in a Cip/Kip-dependent manner because DU-p21+p27 cells were completely resistant to IP6-induced apoptosis both in cell culture and xenograft. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 11 | Together, these results provide evidence, for the first time, of the critical role of p21 and p27 in mediating the anticancer efficacy of IP6, and suggest their redundant role in the antiproliferative and proapoptotic effects of IP6 in p53-lacking human PCa cells, both in vitro and in vivo. | Phytic Acid | cyclin dependent kinase inhibitor 1A | Homo sapiens |