PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19176374-0	2009	p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.	Phytic Acid	57-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3	
19176374-0	2009	p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.	Phytic Acid	57-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8	
19176374-1	2009	Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53.	Phytic Acid	0-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100	
19176374-1	2009	Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53.	Phytic Acid	0-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105	
19176374-1	2009	Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53.	Phytic Acid	24-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100	
19176374-1	2009	Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53.	Phytic Acid	24-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105	
19176374-6	2009	In tumor xenograft studies, IP6 (2% w/v, in drinking water) caused a comparable reduction in tumor volume (40-46%) and tumor cell proliferation (26-28%) in DU-EV (control), DU-p21, and DU-p27 tumors but lost most of its effect in DU-p21+p27 tumors.	Phytic Acid	28-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-179	
19176374-6	2009	In tumor xenograft studies, IP6 (2% w/v, in drinking water) caused a comparable reduction in tumor volume (40-46%) and tumor cell proliferation (26-28%) in DU-EV (control), DU-p21, and DU-p27 tumors but lost most of its effect in DU-p21+p27 tumors.	Phytic Acid	28-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	233-236	
19176374-7	2009	IP6-caused apoptosis also occurred in a Cip/Kip-dependent manner because DU-p21+p27 cells were completely resistant to IP6-induced apoptosis both in cell culture and xenograft.	Phytic Acid	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-79	
19176374-7	2009	IP6-caused apoptosis also occurred in a Cip/Kip-dependent manner because DU-p21+p27 cells were completely resistant to IP6-induced apoptosis both in cell culture and xenograft.	Phytic Acid	119-122	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-79	
19176374-8	2009	Together, these results provide evidence, for the first time, of the critical role of p21 and p27 in mediating the anticancer efficacy of IP6, and suggest their redundant role in the antiproliferative and proapoptotic effects of IP6 in p53-lacking human PCa cells, both in vitro and in vivo.	Phytic Acid	138-141	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-89