Title : The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.

Pub. Date : 2009 Sep

PMID : 19157634






2 Functional Relationships(s)
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1 In this study, we characterize the role of celecoxib in the cytotoxicity, ERK1/2 activation and Rad51 expression affected by gefitinib in NSCLC cells. Celecoxib mitogen-activated protein kinase 3 Homo sapiens
2 Furthermore, blocking ERK1/2 activation by U0126 (MKK1/2 inhibitor) and knocking down Rad51 expression by transfection with small interfering RNA of Rad51 can enhance the cytotoxicity of celecoxib. Celecoxib mitogen-activated protein kinase 3 Homo sapiens