Title : Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.

Pub. Date : 2009 Mar 27

PMID : 19153082






1 Functional Relationships(s)
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1 The x-ray structures revealed surprising conformational changes of the binding cleft of HdmX, including an "open conformation" of Tyr(99) and unexpected "cross-talk" between the Trp and Leu pockets. Leucine MDM2 proto-oncogene Homo sapiens