Pub. Date : 2009 Mar
PMID : 19150461
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Astrocytes from Gclm (-/-) mice, which lack the modifier subunit of glutamate cysteine ligase and, as a consequence, have very low GSH levels, were much less effective at protecting CGNs from DE-71 toxicity. | Glutathione | glutamate-cysteine ligase, modifier subunit | Mus musculus |
| 2 | The protective effects were mostly due to the ability of Gclm (+/+) astrocytes to increase GSH levels in neurons. | Glutathione | glutamate-cysteine ligase, modifier subunit | Mus musculus |
| 3 | Since several polymorphisms, including some in the Gclm gene, cause very low levels of GSH, it may be speculated that such individuals might display a higher susceptibility to the neurotoxic effects of PBDEs. | Glutathione | glutamate-cysteine ligase, modifier subunit | Mus musculus |