Title : Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

Pub. Date : 2009 Apr

PMID : 19147812






3 Functional Relationships(s)
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1 In this study, we show that lysophosphatidic acid (LPA) induces alphavbeta6-mediated TGF-beta activation in human epithelial cells via both RhoA and Rho kinase. lysophosphatidic acid ras homolog family member A Homo sapiens
2 In this study, we show that lysophosphatidic acid (LPA) induces alphavbeta6-mediated TGF-beta activation in human epithelial cells via both RhoA and Rho kinase. lysophosphatidic acid ras homolog family member A Homo sapiens
3 These studies demonstrate that LPA induces alphavbeta6 integrin-mediated TGF-beta activation in epithelial cells via LPA2, G alpha(q), RhoA, and Rho kinase, and that this pathway might be clinically relevant to the development of lung injury and fibrosis. lysophosphatidic acid ras homolog family member A Homo sapiens