Title : Phosphodiesterase type-5 inhibitor and oxidative stress.

Pub. Date : 2008 Oct-Dec

PMID : 19144273






1 Functional Relationships(s)
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1 The aim of this work is to test the action of three common phosphodiesterase inhibitors: Tadalafil, Sildenafil Citrate and Vardenafil at 0.05 microM on human monocytes, analyzing the expression of iNOS protein and mRNA by Western blot and rt-PCR, and production of NO by conversion of L-(2,3,4,5)-[3H]Arginine to L-(3H) citrulline. Sildenafil Citrate nitric oxide synthase 2 Homo sapiens