Title : Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.

Pub. Date : 2009 Mar 13

PMID : 19139102

1 Functional Relationships(s)
Compound Name
Protein Name
1 Mutation of the FERM domain of JAK1, which is critical for cytokine receptor association, or of the single tyrosine of IL-9Ralpha involved in STAT recruitment abolished this activity, indicating that JAK1 mutants need to associate with a functional IL-9Ralpha to activate STAT factors. Tyrosine Janus kinase 1 Homo sapiens