Pub. Date : 2008 Nov
PMID : 19138991
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |