Title : Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding.

Pub. Date : 2009 Jan 7

PMID : 19129404






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding. Catecholamines neuropeptide Y Homo sapiens
2 Catecholamine/NPY cell bodies are concentrated in the A1 and caudal C1 cell cluster (A1/C1) in the ventrolateral medulla, a region highly sensitive to glucoprivic challenge. Catecholamines neuropeptide Y Homo sapiens
3 To further investigate the importance of this catecholamine subpopulation in glucoregulation, we used small interfering RNA (siRNA) technology to produce a targeted gene knockdown of NPY and dopamine-beta-hydroxylase (DBH), a catecholamine biosynthetic enzyme. Catecholamines neuropeptide Y Homo sapiens