Protein Name neuropeptide Y
Organism Homo sapiens
Gene ID 4852
Gene Symbol


UniProt P01303 (NPY_HUMAN), A4D158 (A4D158_HUMAN)
Relationships Total Number of functionally related compound(s) : 653
Total Number of Articles : 1049

neuropeptide Y

Gene Summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

  • pro-neuropeptide Y
  • prepro-neuropeptide Y
  • PYY4
Click to show/hide the synonyms