Title : Chronic isolation of adult rats decreases gene expression of catecholamine biosynthetic enzymes in adrenal medulla.

Pub. Date : 2008 Dec

PMID : 19112418






3 Functional Relationships(s)
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1 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines tyrosine hydroxylase Rattus norvegicus
2 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines tyrosine hydroxylase Rattus norvegicus
3 The results indicate a possible adaptation of catecholamine-synthesizing system at the level of TH gene expression in adrenal medulla of chronically isolated animals. Catecholamines tyrosine hydroxylase Rattus norvegicus