Title : Effects of propofol on the mRNA expression of toll-like receptor 4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro.

Pub. Date : 2008 Dec

PMID : 19107373






5 Functional Relationships(s)
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1 Effects of propofol on the mRNA expression of toll-like receptor 4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro. Propofol toll-like receptor 4 Mus musculus
2 This study investigated the effects of propofol on the mRNA expression of Toll-like receptor-4 (TLR4) in BV-2 cells during mimic ischemia-reperfusion (I/R) injury in vitro. Propofol toll-like receptor 4 Mus musculus
3 This study investigated the effects of propofol on the mRNA expression of Toll-like receptor-4 (TLR4) in BV-2 cells during mimic ischemia-reperfusion (I/R) injury in vitro. Propofol toll-like receptor 4 Mus musculus
4 After pre-treatment with propofol, the mRNA expressions of TLR4 and NF-kappa B and the TNF-alpha level were significantly decreased in groups PF(25) and PF(100) in comparison to those in group I/R (P<0.01). Propofol toll-like receptor 4 Mus musculus
5 It was concluded that propofol exerted brain-protecting effects during I/R injury by suppressing the mRNA expressions of TLR4 and NF-kappaB and deceasing the TNF-alpha level. Propofol toll-like receptor 4 Mus musculus