Pub. Date : 2009 Mar
PMID : 19103263
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among the oxidative systems tested, the ascorbate/Cu(2+) system was the most potent in inactivating the lactonase activity of purified PON1; in contrast to a limited role of Fe(2+), Cu(2+) (0.05-1.0 microM) remarkably enhanced the inactivation of PON1 in the presence of ascorbate (0.02-0.1 mM). | Ascorbic Acid | paraoxonase 1 | Homo sapiens |
| 2 | Among the oxidative systems tested, the ascorbate/Cu(2+) system was the most potent in inactivating the lactonase activity of purified PON1; in contrast to a limited role of Fe(2+), Cu(2+) (0.05-1.0 microM) remarkably enhanced the inactivation of PON1 in the presence of ascorbate (0.02-0.1 mM). | Ascorbic Acid | paraoxonase 1 | Homo sapiens |
| 3 | Among the oxidative systems tested, the ascorbate/Cu(2+) system was the most potent in inactivating the lactonase activity of purified PON1; in contrast to a limited role of Fe(2+), Cu(2+) (0.05-1.0 microM) remarkably enhanced the inactivation of PON1 in the presence of ascorbate (0.02-0.1 mM). | Ascorbic Acid | paraoxonase 1 | Homo sapiens |
| 4 | The ascorbate/Cu(2+)-mediated inactivation of PON1 lactonase activity was prevented by catalase, but not general hydroxyl radical scavengers, suggesting the implication of Cu(2+)-bound hydroxyl radicals in the oxidative inactivation. | Ascorbic Acid | paraoxonase 1 | Homo sapiens |
| 5 | Taken together, our data demonstrate that Cu(2+)-catalyzed oxidation may be a primary factor to cause the decrease of PON1 lactonase activity under oxidative stress and that lactonase activity of PON1 is most susceptible to ascorbate/Cu(2+) among PON1 activities. | Ascorbic Acid | paraoxonase 1 | Homo sapiens |
| 6 | Taken together, our data demonstrate that Cu(2+)-catalyzed oxidation may be a primary factor to cause the decrease of PON1 lactonase activity under oxidative stress and that lactonase activity of PON1 is most susceptible to ascorbate/Cu(2+) among PON1 activities. | Ascorbic Acid | paraoxonase 1 | Homo sapiens |